Jeffrey Modell Centers Network

Established to meet the critical need for expert referral centers worldwide, the JMCN now spans 93 countries with 930 physicians serving more than 265,000+ patients. Our network advances the field of immunology through cross-continental collaboration, groundbreaking research initiatives, and improved access to specialized care.

Clinical Excellence & Research Impact

Clinical Excellence & Research Impact

What is the JMCN?

The Jeffrey Modell Centers Network serves as the global standard for specialized Primary Immunodeficiency care and research. JMCN member centers provide:

• Expert Diagnosis: Immunologists trained in latest IUIS PI classification
• Advanced Treatment: Immunoglobulin replacement, stem cell transplant, and gene therapy
• Clinical Research: Collaborative studies with international patient database access
• Professional Education: Regional toolkits, educational materials, and clinical guidelines in multiple languages

Evidence-Based Growth: Research in Allergy Asthma Clinical Immunology (Quinn et al., 2022) demonstrates 4,250% growth in diagnosed patients (2003-2021), 200% physician growth, and 191% institutional expansion.

Network Research Capabilities

JMCN members contribute to immunology advancement through:

• Collaborative Studies: Multi-center research with investigators across continents
• Patient Database Access: De-identified data from 265,000+ patient encounters for epidemiological and outcome studies
• Research Funding: Apply for Jeffrey Modell Foundation grants including Translational Research and Specific Defect Research
• Precision Medicine: Participate in Jeffrey's Genetic Insights Program offering whole exome sequencing and genetic consultation
• Annual Physician Survey: Contribute clinical insights capturing treatment modalities, patient demographics, and diagnostic patterns

Clinical Tools & Resources

Clinical Tools & Resources

Advanced Diagnostic Support

JMCN members access clinical decision support tools:

• SPIRIT Analyzer: Software for immunology laboratory result analysis and interpretation
• Genetic Sequencing: Free whole exome sequencing through Jeffrey's Genetic Insights Program for eligible patients
• Expert Consultation Network: Connect with JMCN immunologists worldwide for complex case collaboration
• Scientific Publications Library: Peer-reviewed research from JMCN investigators and the broader PI community

Educational Resources for Healthcare Professionals

Evidence-based educational materials to enhance clinical practice:

• Regional PI Toolkits: Physician guides with diagnostic criteria, treatment algorithms, and patient materials—available for Africa, Asia, Australia, Europe, Latin America, and Middle East
• Clinical Guidelines: Current recommendations for immunoglobulin therapy, infection prophylaxis, and immunization schedules
• Newborn Screening Initiatives: Resources for implementing and advocating for SCID newborn screening programs
• Educational Posters and Materials: Professional resources for patient education and medical training

Join the Global Research Effort

Join the Global Research Effort

JMCN Physician Survey: Advancing Knowledge Together

JMCN members advance collective understanding of Primary Immunodeficiencies through our annual Physician Survey capturing:

• Treatment Patterns: Immunoglobulin protocols, antimicrobial prophylaxis, and emerging therapies
• Patient Demographics: Age at diagnosis, geographic distribution, and factors affecting care access
• Diagnostic Approaches: Laboratory protocols, genetic testing, and time from symptoms to diagnosis
• Clinical Outcomes: Treatment efficacy, infection rates, quality of life, and prognosis data

Research Value: Survey data informs practice guidelines, identifies clinical needs, and supports grant applications. Data is analyzed and made available to JMCN members for publication and international conferences.

Survey Platform: JMCN members receive credentials to our dedicated survey platform to submit data, review network statistics, download datasets (with IRB approval), and collaborate on multi-center studies.

Membership Benefits & Network Collaboration

Membership Benefits & Network Collaboration

Why Join the JMCN?

Membership provides:

1. Global Recognition: Designation signals clinical excellence and research expertise to patients, referring physicians, and institutional leadership
2. Research Opportunities: Priority access to grants, collaborative study networks, and international patient databases
3. Professional Development: Annual JMCN symposia, expert webinars, and CME-accredited programs
4. Clinical Resources: Complimentary SPIRIT Analyzer software, genetic sequencing for eligible patients, and multilingual toolkits
5. Patient Referral Network: Direct connections with JMCN colleagues worldwide for complex cases and second opinions
6. Advocacy Support: Partnership advancing newborn screening, insurance coverage, and research funding

Network Collaboration in Action

JMCN research includes:

• Longitudinal outcomes studies of immunoglobulin therapy across diverse populations
• Genetic mutation registries identifying novel PI-causing variants
• Quality of life research demonstrating early diagnosis impact through newborn screening
• Treatment protocol optimization comparing subcutaneous vs. intravenous immunoglobulin
• Health economics analyses supporting insurance coverage for PI therapies

Publication Support: Our research team assists with manuscript preparation, biostatistical analysis, and journal submission.

Global Collaboration

JMCN physicians collaborate across continents to advance Primary Immunodeficiency diagnosis, treatment, and research through our network of 93 countries.

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Ready to Join the JMCN Network?

Email us at research@jmfworld.org