Earlier this year, we published a new manuscript highlighting the growth and diagnosis and treatment of PI within the JMCN. Over the years we’ve developed a survey to send to members of the Jeffrey Modell Centers Network (JMCN) to describe their patient population and better understand diagnosis, treatment, demographics, and most prevalent types of PI seen and diagnosed.

Based on the survey results, the ten most common PIs have remained consistent over the past eight years, with only minor differences. The most prevalent PI identified globally was Common Variable Immunodeficiency (CVID). Here are the top ten most commonly identified PIs within the JMCN:

  1. Common Variable Immunodeficiency (CVID)
  2. Selective IgA deficiency
  3. Isolated IgG subclass deficiency
  4. TBX1 (DiGeorge, Chromosome 22q11.2 Deletion Syndrome), AD
  5. Transient hypogammaglobulinemia of Infancy
  6. Specific antibody deficiency (normal Ig and B cells)
  7. ATM (Ataxia-telangiectasia), AR
  8. BTK (BTK deficiency, XLA) XL
  9. MEFV (Familial Mediterranean fever), AD
  10. TNFRSF13B (TACI deficiency), AR or AD

Visit the Encyclopedia page of our website to find detailed definitions about specific PIs. Interested in reading more about our survey results? You can read the full article and additional findings here: https://aacijournal.biomedcentral.com/articles/10.1186/s13223-022-00662-6.