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  • Understand Primary Immunodeficiency and its warning signs. Connect with expert immunologists.
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10 Warning Signs of Chronic granulomatous disease (CGD)

Chronic granulomatous disease (CGD) is a rare inherited primary immunodeficiency disorder that impairs the body's ability to kill certain bacteria and fungi. As a result, people with CGD are at a higher risk for getting severe, unusual, and repeat infections.

  1. Serious, unusual, and repeat infections in many areas of the body(including the lungs, liver, and bones)
  2. Skin and soft tissue abscesses that don't go away
  3. Diarrhea or abdominal pain
  4. Pain or difficulty eating or going to the bathroom
  5. Vomiting after meals
  6. Swollen lymph nodes
  7. Fever, cough, fatigue, or bone/joint pain
  8. Failure to thrive
  9. Granulomas(which usually appear in the bladder and intestines)
  10. Family members or relatives who have had unusual or serious infections(that have resulted in hospitalizations or even death)
  • 10 Warning Signs of CGD

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  • The Roots of CGD

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  • How to Recognize CGD

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If you or someone you know is experiencing any symptoms of Primary Immunodeficiency, the 4 Stages of Testing provides a structured diagnostic pathway. This evidence-based framework helps physicians accurately diagnose PI and has been translated into dozens of languages to enhance early diagnosis worldwide.

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If you are experiencing any above the above symptoms you can explore next steps in the 4 Stages of Testing.
  • 10 Warning Signs of APDS
  • 10 Warning Signs of WHIM

In 2024, The Jeffrey Modell Foundation received the highest four-star rating from Charity Navigator for the 9th consecutive year, ranking #1 in Immunology out of 10,000 organizations evaluated worldwide.

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