International Plasma Awareness Week (October 5-9) is a time to recognize plasma donors and the difference they make for people living with Primary Immunodeficiency. 

Thank you to every plasma donor. Your donations make lifesaving treatment for Primary Immunodeficiency possible!

If you've ever thought about donating but weren't sure where to start, this guide walks you through everything you need to know about donating plasma.

Why Does Plasma Donation Matter for Primary Immunodeficiency?

Plasma cannot be made in a lab, so every plasma-derived treatment starts with a person who chooses to donate. For many people living with Primary Immunodeficiency, immunoglobulin replacement therapy made from donated plasma is the treatment that keeps them well. It takes about 130 plasma donations a year to support one person's Primary Immunodeficiency treatment.

Who Can Donate Plasma?

Generally, you can donate plasma if you:

  • Are 18 years or older
  • Weigh at least 110 pounds
  • Are in overall good health

You'll also need a valid photo ID and proof of address. Requirements can vary by donation center, so check with your local center before your first visit.

How Do I Find a Plasma Donation Center?

You can find a plasma donation center near you at pptaglobal.org/donate.

What Happens When I Donate Plasma?

Check-in and screening. When you arrive, you'll complete a health questionnaire and have your vitals checked. Staff will do a quick finger stick to check your iron and protein levels. First-time donors also complete a brief physical exam.

The donation. A sterile needle is placed in a vein in your arm. Your blood goes into a machine that separates the plasma from your red blood cells, white blood cells, and platelets. Your plasma is collected, and the rest is returned to your body. This process is called plasmapheresis.

Plasma donation is different from blood donation. Learn more about the differences between blood donation and plasma donation here. 

Recovery. After donating, you'll rest for a few minutes and have a drink and a snack before heading home.

Your first appointment typically takes about two hours. After that, most appointments take about 90 minutes.

How Can I Prepare to Donate Plasma?

  • Drink plenty of water the day before and the day of your appointment
  • Eat a healthy meal that includes protein and iron
  • Avoid fatty foods before donating
  • Get a good night's sleep

How Often Can I Donate Plasma?

In the United States, you can donate plasma up to twice in a seven-day period, with at least one day in between donations. Your body replaces the plasma you donate within about 24 to 48 hours.

How Does My Plasma Become Treatment for Primary Immunodeficiency?

After you donate, your plasma is tested for safety and quality, frozen, and delivered to pharmaceutical companies. It is then combined with thousands of other donations and processed to separate out specific proteins. Those proteins become the medicine that people living with Primary Immunodeficiency rely on every day.